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1: J
Bacteriol. 2001 May; 183(10): 2971-8.

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Divergence in fitness and evolution of drug
resistance in experimental populations of Candida
albicans.

Cowen LE, Kohn LM, Anderson
JB.

Department of Botany, University of Toronto, Mississauga,
Ontario, Canada L5L 1C6. [email-masked]

The
dissemination and persistence of drug-resistant organisms in nature
depends on the relative fitness of sensitive and resistant genotypes.
While resistant genotypes are expected to be at an advantage compared to
less resistant genotypes in the presence of drug, resistance may incur a
cost; resistant genotypes may be at a disadvantage in the absence of
drug. We measured the fitness of replicate experimental populations of
the pathogenic yeast Candida albicans founded from a single progenitor
cell in a previous study (L. E. Cowen, D. Sanglard, D. Calabrese, C.
Sirjusingh, J. B. Anderson, and L. M. Kohn, J. Bacteriol. 182:1515-1522,
2000) and evolved in the presence, and in the absence, of the antifungal
agent fluconazole. Fitness was measured both in the presence and in the
absence of fluconazole by placing each evolved population in direct
competition with the drug-sensitive ancestor and measuring the
reproductive output of each competitor in the mixture. Populations
evolved in the presence of drug diverged in fitness. Any significant
cost of resistance, indicated by reduced fitness in the absence of drug,
was eliminated with further evolution. Populations evolved in the
absence of drug showed more uniform increases in fitness under both
conditions. Fitness in the competition assays was not predicted by
measurements of the MICs, doubling times, or stationary-phase cell
densities of the competitors in isolation, suggesting the importance of
interactions between mixed genotypes in competitions.

PMID:
11325923 [PubMed - indexed for MEDLINE]

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